講座人：滿恒業(yè) 教授 波士頓大學(xué)

時間：10:00

日期：2019-07-05

地點(diǎn)：長安校區(qū) 格物樓3201會議室

內(nèi)容簡介：

X-linked KIAA2022/KIDLIA gene is a new autism gene. We have successfully created a KIAA2022 knockout mouse model which shows typical autism phenotypes as well as impairments in learning and memory. We find that loss of KIAA2022 results in suppression of dendritic growth, a decrease in spine number, synapse formation and synaptic transmission. We are investigating the underlying molecular mechanisms and also exploring means to rescue the molecular dysregulation and behavioral deficits in KIAA2022/KIDLIA knockout mice with the aim to provide therapeutic tools for clinical management of the disorder.

講座人簡介：

滿恒業(yè)教授,，美國波士頓大學(xué)生物系副主任,、博士生導(dǎo)師,，生物系終身教授,。擔(dān)任多家雜志包括Neuron、Nature Neuroscience等的審稿人,，美國NIH,、英國醫(yī)學(xué)研究委員會等基金的評審,。兩次獲得美國腦與行為基金會的青年科學(xué)家獎,。主要科研方向包括突觸生成及可塑性,，谷氨酸受體動態(tài)分布及蛋白穩(wěn)定性的調(diào)節(jié)機(jī)制，神經(jīng)細(xì)胞形態(tài)發(fā)育,，神經(jīng)發(fā)育性和退行性疾病等的細(xì)胞分子機(jī)制。在多種雜志包括Nature,、Science,、Cell、Neuron,、Cell Reports,、J Neuroscience、PNAS等發(fā)表文章70余篇,。